Our mission
The evidences of MicroRNA cross-kingdom between microbes, plant, humans and animals, the application of microRNA to cancer early diagnostic et possible therapy, the role of MicroRNA in nutrition and metabolic disease, and their effect in inflammation and in the immune response,, have open the vision to the role of MicroRNA’s in global health.
MirNat Global Health mission is to bridge the gap between traditional and modern medicine with One Health approach, as North-South-South collaborative effort. Mir-Nat Global Health through a scientific and responsible approach uses extensive in silico, in vitro and in vivo studies to investigate the molecular and genetic basis of several pathologies, including infections, cancers, chronic inflammation, metabolic disorders, and ageing.
Identifying nutritional microRNAs with AI
For the first time, bioinformatics and artificial intelligence are used to identify plant microRNAs with a valuable nutritional support for prevention and treatment of several diseases. More importantly, bioinformatics and AI provide precious tools for identification of potential molecular mechanisms underlying genetic cross-kingdom regulation, which are subsequently explored using traditional molecular approaches.
More recently, we have integrate molecular, bioinformatic and AI evidences on the role of microRNAs present in the exosomes of Camel milk, developing nutraceutical perspectives on metabolic diseases and aging.
We develop new approaches of analysis
Based on the strong evidence that plant miRNAs inside mammalian cells use the endogenous machinery for post-transcriptional regulation of target genes, we developed MirCompare, an innovative model that predict plant microRNAs with a regulatory, active role in mammalian cells. MirCompare is integrated in a fast and user-friendly interface and is publicly available here. If you want to read the peer-reviewed publication, here you can find our manuscript.
The growth of interest on microRNAs and the increasing amount of literature, molecular and biomedical data, make difficult to identify records of interest as well as keep up to date with the novel findings. For these reasons we developed MAP, the microRNAs Analysis Portal.
MAP selects miRNA-focused relevant articles from PubMed, links biomedical and molecular data and applies bioinformatics modules. Currently MAP represents the most rich, complete and integrated database focused on microRNAs.